![]() 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. Townsend Letter for Doctors and Patients. Recent findings on N, N-dimethylglycine (DMG): a nutrient for the new millennium. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Intake and supplementation with DMG plays an important role in keeping Hcy levels stable and providing methyl donors. īecause it contains two methyl groups for donation, therapeutic interventions with DMG have been successful in many conditions including autism, hyperlipidemia, chronic fatigue syndrome, systemic lupus erythematosus, and cardiovascular disease. It was used in the Soviet Union in the 1960’s as part of a formula to benefit athletic performance. Dietary sources include cereal grains, seeds, beans and liver. Ĭlinically, DMG elevations may indicate an increase in activity of the BHMT “salvage-pathway.” Therefore, high DMG may reflect the need for additional folate, vitamin B12, and zinc.ĭMG has been marketed safely as a nutritional supplement since 1974. Elevations in DMG act as a negative feedback by inhibiting this enzymatic conversion. This methyl donation is mediated by the enzyme betaine homocysteine methyltransferase (BHMT). The amino acid derivative dimethylglycine (DMG) is produced when betaine (trimethylglycine) donates a methyl group to homocysteine for re-methylation back to methionine.
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